The Effect of 6-mercaptopurine and Aminopterin on Experimental Immune Thyroiditis in Guinea Pigs

The Effect of 6-mercaptopurine on Delayed Hypersensitivity in Guinea Pigs

The development of tuberculin hypersensitivity in guinea pigs after BCG stimulation was suppressed by intramuscular administration of 50 mg/kg/day of 6-mercaptopurine started at the time of stimulation. Fasting of guinea pigs after BCG stimulation had no effect on the development of tuberculin hypersensitivity.

Evaluation of Acute Aflatoxicosis on Humoral Immune Response to Foot-and Mouth Disease Vaccination in Guinea Pigs

Effect of vitamin C on tracheal responsiveness and pulmonary inflammation in chronic obstructive pulmonary disease model of guinea pig

Introduction: In the present study, the prophylactic effect of vitamin C, as a potent anti-oxidant, on tracheal responsiveness to methacholine and ovalbumin, bronchoalveolar lavage fluid white blood cell (WBC) count and differential count, and also lung pathology in chronic obstructive pulmonary disease (COPD) -guinea pigs (cigarette exposed guinea pigs) were examined. In addition, the relax...

Effect of Aminopterin Administration on the Metabolism of Liver and Small Intestine of Guinea Pigs and Rats*

Small amounts of Aminopterin, one of the antifolic metabolites, produce gastrointestinal effects such as nausea, vomiting, melena, and diarrhea in human beings (1, 2) and destruction of the epithelial elements in experimental animals (3, 4). A single injection of 240 y of Aminopterin per kilo of body weight had no morphological effect when administered to young adult rats, but caused a marked r...

Evaluation of the Effect of Onosma Bracteatum Wall (Boraginaceae) On Bronchial Hyperreactivity in Sensitized Guinea Pigs

Asthma is a chronic inflammatory disorder of the airways. The available treatment options have major limitations owing to low efficacy, associated adverse events and compliance issues. Therefore, the health burden of bronchial asthma is increasing globally at an alarming rate, providing a strong impetus for the development of new therapeutics. Onosma bracteatum ( O. bracteatum ) is know...